AF CLINICAL RESEARCH

The Brisbane AF Clinic is dedicated to furthering knowledge and treatments of AF and education about AF. Dr Karen Phillips is involved in active research with regular presentation of clinical abstracts at cardiac scientific meetings and continued publication in peer- reviewed medical journals. Dr Karen Phillips has been a Principal Investigator for several international clinical trials on leading edge AF treatments.

CLINICAL TRIALS FOR AF

Cardialen MultiPulse Therapy (MPT) for AF

The purpose of this study was to assess the clinical safety and feasibility of MultiPulse Therapy (MPT) electrical stimulation waveform sequence in terminating paroxysmal and persistent atrial fibrillation in a patient group undergoing catheter ablation treatment for AF.

OPTION ‘Comparison of Anticoagulation With Left Atrial Appendage Closure After AF Ablation’

The primary objective of this study was to determine if left atrial appendage closure with the WATCHMAN FLX Device is a reasonable alternative to oral anticoagulation following percutaneous catheter ablation for high risk patients with atrial fibrillation.

AMPLATZER™ Amulet™ LAA Occluder Trial (Amulet IDE)

The purpose of this study was to evaluate the Amulet™ device for safety and efficacy by comparing its performance to the commercially available WATCHMAN® left atrial appendage closure device in patients with non-valvular atrial fibrillation. Patients who are eligible for the trial will be randomized to receive either the Amulet device or the WATCHMAN device and will be followed for 5 years after device implant.

WASP (Watchman Asia Pacific Real World Outcomes) Registry

This was an observational, prospective, non-randomized, multicenter study with the following objectives: (1) to compile real-world clinical outcomes data for WATCHMAN Left Atrial Appendage Closure Technology in patients who are implanted with the WATCHMAN device in a commercial clinical setting and (2) to collect health care usage data that may be needed for reimbursement of WATCHMAN technology in certain countries.

ZERO-AF “Clinical Evaluation of the Blazer Open-Irrigated Ablation Catheter for the Treatment of Paroxysmal Atrial Fibrillation”

The purpose of this study was to establish the safety and effectiveness of the Blazer Open-Irrigated radiofrequency ablation catheter for the treatment of drug refractory, recurrent, symptomatic, paroxysmal atrial fibrillation.

Coherex WaveCrest® Left Atrial Appendage Occlusion Study

The purpose of this study was a “first in man” assessment of the WaveCrest device which is designed to be placed in the opening of the left atrial appendage (LAA) to prevent stroke in patients with atrial fibrillation.